Many chromatographers prefer a C8 column when an ODS phase shows excessive retention values. Inertsil C8-4 provides the same separation pattern (selectivity) and extreme inertness to any type of compounds just like Inertsil ODS-4, which enables easy method transfer from ODS4 to C8-4 while other commercially available ODS and C8 columns can show dramatically different selectivity even though they are part of the same brand/series.