GL Sciences has established a successful manufacturing process for ultra pure silica gel with smooth and rigid surface. The SEM photos of Inertsil SIL-100A and other brands’ silica gel are shown as Figure 1. Particles of Inertsil SIL-100A stand out by the smooth surface, uniformity in size and spherical shape. From Figure 2, we can know as silanols on the sIlica surface interact with basic compounds, Inertsil SIL-100A retains basic compounds strongly and acidic compounds weakly.