It is indeed difficult to retain highly polar samples by reversed phase mode as the polar samples tend to elute near the t0 (void volume) with water rich mobile phases. On the other hand, polar embedded C18 columns or C18 columns with hydrophilic endcapping are available in the market for retaining highly polar compounds. However, they often show tailing or poor peak shapes due to the secondary interaction from their embedded functional groups.
InertSustain AQ-C18 columns not only provide strong retention for highly polar compounds, but also delivery symmetric peak shapes for virtually any type of analytes.
As shown below, InertSustain AQ-C18 columns delivered stronger retention of catechin sample even under 20% organic solvent mobile phase with exceptional peak shapes, while competitive column brand failed. Furthermore, InertSustain AQ-C18 can prevent the co-elution between the targeted polar analytes and solvent peaks or sample matrices due to its enhanced retentivity.
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InertSustain AQ-C18 Capillary EX-Nano Column, 3 µm, 50 x 0.2 mm